The ABC Platform
Inspired by Nature, Designed with Water in Mind.
The ABC Platform is at the heart of our portfolio of retina medicines.
This innovative platform uses our bio-inspired polymer to orchestrate water around a purpose-built antibody to power new and enduring capabilities.
The ABC Platform creates a water force field around the antibody without obstructing the binding sites.
This makes the bioconjugate optically clear and imbues it with special properties because it focuses the antibody on its target while shielding it from non-targets during its journey.
The ABC Platform
Precision engineered for increased durability and efficacy
Same Where It Matters
- Clinically proven targets
- Antibody-based biologic
- Intravitreal injection: 25M+ per year
- Optically clear, no residues
- Fast and potent clinical responses
Different Where It Counts
- Designed-in ocular durability
- Designed-in rapid systemic clearance
- Improved bioavailability
- Improved biocompatibility
- Improved stability
The bioconjugate harnesses the power of water. Water strongly influences the behavior of a molecule in its local environment.
Explore the role water plays in these key attributes of our ABC Platform.
- NATURE'S ZWITTERION
- STRUCTURED, MACROMOLECULAR WATER
- STEREOSPECIFIC DOCKING
- FAST SYSTEMIC CLEARANCE
The biopolymer is made of phosphorylcholine, a building block of our cell membranes. Phosphorylcholine is electroneutral (a zwitterion) and biocompatible.
Phosphorylcholine is special because it is the strongest water-binding zwitterion. It attracts and binds water in a strong and permanent way.
The Role of Zwitterionic Phosphorylcholine in Nature
The Role of Zwitterionic Phosphorylcholine in the ABC Platform
On the external surface of our cells is the phospholipid bilayer, made of hydrophilic phosphorylcholine head groups and lipid tails.
Phosphorylcholine is a zwitterion (a balance of positive and negative), enabling it to attract and permanently bind water molecules.
This hydrophilic phosphorylcholine creates a water microenvironment in which water molecules are structured — irreversibly bound at the cell surface to the phosphorylcholine groups, forming a kind of “liquid ice”.
This water microenvironment is important because it conditions and participates in local biomolecular interactions.
Biopolymer binding to water creates structured water layers.
In the ABC Platform, each biopolymer arm contains many hundreds of phosphorylcholine molecules – the strongest water binding zwitterion.
Each arm binds a tremendous amount of water very tightly. The water becomes less structured or loose farther away from the phosphorylcholine molecules.
STRUCTURED, MACROMOLECULAR WATER
In essence these water layers provide radial coverage of the bioconjugate like a force field – without obstructing the binding sites. This is called "structured, macromolecular water."
This makes our ABC medicines optically clear and imbues them with new and special properties.
See Why By Traveling Through the Eye
ABC Leaving the Eye
THE ABC PLATFORM
The First Bio-Inspired Water Enhanced Biologic
Antibody Biopolymer Conjugate (ABC) Platform
The antibody and biopolymer are stably bound to create a bioconjugate.
The bioconjugate enters and exits the eye intact leaving no residual material.
The stable, single-site specific linkage is non-degradative and non-erodible.